Bone Biology - Osteoblasts and Osteoclasts animation


Bone is a living organ that is continuously being reshaped in a process called remodeling. In this process, cells called osteoclasts resorb bone tissues whereas cells called osteoblasts deposit new bone tissue. Osteoblasts can become trapped within the bone matrix they secrete, promoting their differentiation into osteocytes. These cells are thought to play an important role in sensing bone load.  Under high loading conditions, osteoblasts increase bone mass, whereas under low loading conditions, osteoclasts remove bone tissue, optimizing its structure. This animation forms part of a series of nine animations that Random42 developed for an interactive website on the processes that occur within bone:

Client: Amgen

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